Plasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca entry
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چکیده
Andreas Bergdahl, Maria F. Gomez, Anna-Karin Wihlborg, David Erlinge, Atli Eyjolfson, Shang-Zhong Xu, David J. Beech, Karl Dreja, and Per Hellstrand Division of Molecular and Cellular Physiology, Department of Physiological Sciences, Lund University, Lund; Departments of Cardiology and Cardiothoracic Surgery, Lund University Hospital, Lund, Sweden; and School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom
منابع مشابه
Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca entry, and basal [Ca ]i in rat distal pulmonary arterial smooth muscle cells
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متن کاملChronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension.
Chronic hypoxic pulmonary hypertension is associated with profound vascular remodeling and alterations in Ca(2+) homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Recent studies show that transient receptor potential (TRPC) genes, which encode store-operated and receptor-operated cation channels, play important roles in Ca(2+) regulation and cell proliferation. However, the influe...
متن کاملPlasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca2+ entry.
Loss of the smooth muscle contractile phenotype is critical in atherosclerosis and in restenosis after angioplasty, but its early signals are incompletely understood. In this study, we have explored the role of transient receptor potential canonical (TRPC) proteins, which have been suggested to mediate store-operated Ca2+ entry (SOCE). Contractility of rat cerebral arteries in organ culture is ...
متن کاملEnhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.
Pulmonary hypertension (PH) is associated with profound vascular remodeling and alterations in Ca(2+) homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Previous studies show that canonical transient receptor potential (TRPC) genes are upregulated and store-operated Ca(2+) entry (SOCE) is augmented in PASMCs of chronic hypoxic rats and patients of pulmonary arterial hypertension (P...
متن کاملChronic Hypoxia-Induced Upregulation of Store-Operated and Receptor-Operated Ca Channels in Pulmonary Arterial Smooth Muscle Cells A Novel Mechanism of Hypoxic Pulmonary Hypertension
Chronic hypoxic pulmonary hypertension is associated with profound vascular remodeling and alterations in Ca homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Recent studies show that transient receptor potential (TRPC) genes, which encode store-operated and receptor-operated cation channels, play important roles in Ca regulation and cell proliferation. However, the influence of c...
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تاریخ انتشار 2005